NAD+

Name: NAD+
SKU: 301
Availability: InStock

NAD+ is crucial for cellular energy production and metabolism. It may improve muscle function, protect nerve cells, and slow aging effects.

Product Usage

This product is designated as a "Novelty Peptide" and is intended solely for specialized applications in controlled settings. It is not intended for any specific biological, therapeutic, or diagnostic use. All information provided on this website is for informational and educational purposes only and should not be construed as guidance for any particular application or usage.

What Is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in all living cells that plays a central role in cellular metabolism and energy production. It functions as an electron carrier in redox reactions and serves as a substrate for various enzymes involved in cellular processes such as DNA repair, gene expression regulation, and cellular signaling. NAD+ levels tend to decline with age, and this decline has been associated with various age-related diseases and metabolic disorders. Consequently, NAD+ has emerged as a promising target for therapeutic interventions aimed at improving healthspan and potentially lifespan.

Structure

Research Findings

Metabolic Regulation: NAD+ plays a crucial role in energy metabolism, serving as a cofactor for enzymes involved in glycolysis, the citric acid cycle, and oxidative phosphorylation.
Sirtuin Activation: NAD+ is a required substrate for sirtuin enzymes, which are involved in various cellular processes including gene expression regulation, DNA repair, and metabolic homeostasis.
DNA Repair: NAD+ is utilized by poly(ADP-ribose) polymerases (PARPs) in the process of DNA repair, helping to maintain genomic stability.
Age-Related Decline: Studies have shown that NAD+ levels decrease with age in various tissues, potentially contributing to age-related cellular dysfunction and disease.
Therapeutic Potential: Preclinical and some clinical studies have demonstrated that boosting NAD+ levels through precursor supplementation or other means may have beneficial effects on metabolic health, cardiovascular function, and neurodegenerative diseases.

Future Research Directions

Long-term Safety Studies: Extended research is needed to evaluate the long-term effects and safety profile of NAD+ boosting interventions in humans.
Optimal Delivery Methods: Investigation into the most effective ways to increase NAD+ levels in specific tissues and cell types.
Clinical Applications: Further clinical trials are required to determine the efficacy of NAD+ boosting strategies in treating or preventing age-related diseases.
Combination Therapies: Exploration of potential synergistic effects of NAD+ boosters with other therapeutic agents or lifestyle interventions.
Mechanism of Action: Additional studies to fully elucidate the molecular mechanisms by which NAD+ and its metabolites influence cellular health and longevity.

References

Poljšak B, Kovač V, Milisav I. Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies. Antioxidants. 2022; 11(9):1638. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495723/
Gilmour BC, et al. The Role of NAD+ in Regenerative Medicine. Cells. 2022; 11(19):3057. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512238/
Mehmel M, et al. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021; 144(22):1795-1817. [Online].
Available: https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.121.056589
Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021; 22(2):119-141. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963035/
Sultani G, et al. NAD+: a key metabolic regulator with great therapeutic potential. J Neuroendocrinol. 2017; 29(10):e12508. [Online].
Available: https://pubmed.ncbi.nlm.nih.gov/28580642/

NAD+ represents a critical metabolic regulator with significant potential for therapeutic interventions in age-related diseases and metabolic disorders. As research progresses, optimizing NAD+ levels may offer new strategies for improving healthspan and potentially lifespan. However, as with all novel therapeutic approaches, careful consideration of long-term safety and efficacy is essential as we continue to explore the potential of NAD+ in human health and disease prevention.

NAD+

Product Usage

What Is NAD+?

Structure

Research Findings

Future Research Directions

References

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