MOTS-C 10MG

Name: MOTS-C 10MG
SKU: 286
Availability: InStock

MOTS-c is a mitochondrial-derived peptide that promotes metabolic balance, improves exercise capacity, and may aid in reducing obesity and insulin resistance.

Product Usage

This product is designated as a "Novelty Peptide" and is intended solely for specialized applications in controlled settings. It is not intended for any specific biological, therapeutic, or diagnostic use. All information provided on this website is for informational and educational purposes only and should not be construed as guidance for any particular application or usage.

What Is MOTS-C 10MG?

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded by the mitochondrial 12S rRNA gene. Discovered in 2015, MOTS-c has emerged as a significant mitochondrial-derived peptide with diverse physiological functions. It plays crucial roles in regulating metabolism, stress responses, and aging-related processes. MOTS-c is unique in its ability to translocate to the nucleus under metabolic stress conditions, where it regulates nuclear gene expression to promote cellular adaptation and homeostasis.

Structure

Research Findings

Metabolic Regulation: MOTS-c has been shown to improve glucose metabolism, enhance insulin sensitivity, and prevent diet-induced obesity. It activates the AMPK pathway, a key regulator of cellular energy homeostasis.
Exercise Mimetic: Studies have demonstrated that MOTS-c can mimic the effects of exercise, improving endurance and muscle function. Its levels increase significantly in skeletal muscle and circulation during exercise.
Stress Response: MOTS-c translocates to the nucleus under metabolic stress, regulating genes with antioxidant response elements (ARE) to promote cellular resilience.
Aging and Longevity: MOTS-c levels decline with age, and its supplementation has shown potential in mitigating age-related metabolic dysfunction and promoting healthy aging.
Neuroprotection: Research indicates that MOTS-c may have neuroprotective effects, potentially benefiting conditions like Alzheimer's disease and other neurodegenerative disorders.

Future Research Directions

Clinical Applications: Further research is needed to explore the therapeutic potential of MOTS-c in treating metabolic disorders, age-related diseases, and neurodegenerative conditions.
Mechanism of Action: More studies are required to fully elucidate the molecular mechanisms by which MOTS-c exerts its diverse effects across different tissue types.
Long-term Safety: Extended studies are necessary to evaluate the long-term effects and safety profile of MOTS-c supplementation in various patient populations.
Delivery Methods: Research into optimal delivery methods and dosing regimens for different conditions could enhance the therapeutic potential of MOTS-c.
Interaction with Other Systems: Investigating how MOTS-c interacts with other cellular signaling pathways and systems could provide a more comprehensive understanding of its physiological roles.

References

Lee, C., et al. (2015). "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell Metabolism, 21(3), 443-454.
Kim, K.H., et al. (2018). "The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress." Cell Metabolism, 28(3), 516-524.e7.
Reynolds, J.C., et al. (2021). "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis." Nature Communications, 12(1), 470.
Zheng, Y., et al. (2023). "MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation." Frontiers in Physiology, 14, 1149120.
Liu, Z., et al. (2023). "MOTS-c functionally prevents metabolic disorders." Nutrients, 15(2), 300.

MOTS-c represents a promising avenue for research in various fields, including metabolism, aging, and stress response. As a mitochondrial-derived peptide with diverse physiological effects, MOTS-c has the potential to revolutionize our approach to treating metabolic disorders and age-related diseases. However, as with all peptide therapies, it is important to approach MOTS-c research with caution, and its potential benefits and risks require ongoing evaluation through further scientific studies and clinical trials.

MOTS-C 10MG

Product Usage

What Is MOTS-C 10MG?

Structure

Research Findings

Future Research Directions

References

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