Kisspeptin 10MG

Name: Kisspeptin 10MG
SKU: 275
Availability: InStock

Kisspeptin regulates reproductive hormones and influences sex-related behaviors. It may also help reverse some aging effects.

Product Usage

This product is designated as a "Novelty Peptide" and is intended solely for specialized applications in controlled settings. It is not intended for any specific biological, therapeutic, or diagnostic use. All information provided on this website is for informational and educational purposes only and should not be construed as guidance for any particular application or usage.

What Is Kisspeptin 10MG?

Kisspeptin-10 is a synthetic decapeptide that represents the minimal biologically active sequence of the kisspeptin family of peptides. It is derived from the C-terminal region of the larger kisspeptin peptides (kisspeptin-54, -14, and -13) and acts as a potent agonist of the kisspeptin receptor (KISS1R). Kisspeptin-10 plays a crucial role in regulating the hypothalamic-pituitary-gonadal (HPG) axis by stimulating gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus, which in turn stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.

Structure

Research Findings

Puberty Regulation: Kisspeptin is crucial for the onset of puberty. Inactivating mutations in KISS1 or KISS1R genes result in hypogonadotropic hypogonadism and failure of pubertal development.
GnRH Stimulation: Kisspeptin is a potent stimulator of GnRH release, subsequently triggering the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.
Reproductive Cycle Regulation: Kisspeptin neurons mediate both positive and negative feedback effects of sex steroids on GnRH secretion, playing a key role in the regulation of the menstrual cycle in females.
Fertility Treatment: Exogenous kisspeptin administration has shown promise in stimulating ovulation in women undergoing in vitro fertilization (IVF) treatment, particularly in those at high risk of ovarian hyperstimulation syndrome.
Metabolic Influence: Kisspeptin signaling serves as an important link between energy balance and reproductive function, with potential implications for conditions like hypothalamic amenorrhea

Future Research Directions

Clinical Applications: Further research is needed to explore the therapeutic potential of kisspeptin in treating various reproductive disorders, including hypothalamic amenorrhea, polycystic ovary syndrome, and delayed puberty.
Long-term Safety: Extended studies are required to evaluate the long-term effects and safety profile of kisspeptin-based therapies in diverse patient populations.
Delivery Methods: Investigation into optimal delivery methods and dosing regimens for different conditions could enhance the therapeutic potential of kisspeptin.
Combination Therapies: Exploring potential synergistic effects of kisspeptin with other therapeutic agents in reproductive medicine.
Non-reproductive Functions: Further research into the roles of kisspeptin in non-reproductive functions, such as metabolism, cardiovascular regulation, and cognitive processes.

References

Patel, B., et al. (2024). The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B. Endocrine Reviews, 45(1), 30-68. [Online].
Available: https://academic.oup.com/edrv/article/45/1/30/7226658
Skorupskaite, K., et al. (2014). The kisspeptin-GnRH pathway in human reproductive health and disease. Human Reproduction Update, 20(4), 485-500. [Online].
Available: https://academic.oup.com/humupd/article/20/4/485/2952658
Comninos, A.N., et al. (2023). Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder. JAMA Network Open, 6(2), e2254632. [Online].
Available: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800937
Ohga, H., et al. (2018). The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis. Frontiers in Endocrinology, 9, 147. [Online].
Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894438/
Hu, K.L., et al. (2019). Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery. Reproductive Biology and Endocrinology, 17, 65. [Online].
Available: https://rbej.biomedcentral.com/articles/10.1186/s12958-019-0511-x

Kisspeptin represents a crucial regulator of reproductive function with significant potential for diagnostic and therapeutic applications in reproductive medicine. As research progresses, kisspeptin-based interventions may offer new treatment options for various reproductive disorders. However, as with all peptide therapies, it is important to approach kisspeptin-based treatments with caution, and their potential

Kisspeptin 10MG

Product Usage

What Is Kisspeptin 10MG?

Structure

Research Findings

Future Research Directions

References

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