GLP-2T

1. Glycemic Control: In clinical trials, GLP-2T demonstrated superior efficacy in reducing HbA1c levels compared to placebo and other diabetes medications, with a maximum reduction of 2.24% observed.
2. Weight Loss: GLP-2T showed significant weight loss effects, with participants losing up to 22.5% of their initial body weight in clinical trials. In the SURMOUNT-1 trial, 36% of participants receiving the highest dose (15 mg) achieved ≥25% weight loss.
3. Cardiometabolic Risk Factors: Treatment with GLP-2T resulted in improvements in various cardiometabolic measures, including blood pressure, fasting insulin levels, and lipid profiles.
4. Prediabetes Reversal: At week 72 of the SURMOUNT-1 trial, 95.3% of participants with prediabetes at baseline who received GLP-2T reverted to normoglycemia, compared to 61.9% in the placebo group.
5. Comparative Efficacy: GLP-2T demonstrated superior efficacy in both glycemic control and weight loss compared to selective GLP-1 receptor agonists like GLP-1 and dulaglutide.

1. Cardiovascular Outcomes: Ongoing trials like SURPASS-CVOT aim to evaluate the long-term cardiovascular effects of GLP-2T in patients with type 2 diabetes.
2. Expanded Indications: Research is underway to explore GLP-2T's potential in treating conditions such as non-alcoholic steatohepatitis (NASH) and obesity-related heart failure with preserved ejection fraction.
3. Combination Therapies: Future studies may investigate the potential synergistic effects of GLP-2T with other therapeutic agents for enhanced metabolic control.
4. Long-term Safety: Extended studies are needed to evaluate the long-term safety profile of GLP-2T, particularly in diverse patient populations.
5. Mechanism of Action: Further research is required to fully elucidate the molecular mechanisms by which GLP-2T exerts its diverse effects, particularly the role of GIP receptor agonism.

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   Available: https://www.drugs.com/tirzepatide.html
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   Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268041/
4. DrugBank. (2024). GLP-2T: Uses, Interactions, Mechanism of Action. [Online].
   Available: https://go.drugbank.com/drugs/DB15171
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   Available: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
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   Available: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB24869395.htm

GLP-2T represents a significant advancement in the treatment of type 2 diabetes and obesity, offering superior efficacy in glycemic control and weight management compared to existing therapies. As with all novel medications, it is important to use GLP-2T under medical supervision, and its potential benefits and risks require ongoing evaluation through long-term clinical use and further research.